- Case
Possible fabricated data: a conspiracy of silence?
I became involved in this issue after reports from doctors in a developing country that three papers in a systematic review published by my company may have been fabricated. The papers in question had co-authors in two other countries and so I contacted them. One co-author replied that he had concerns, but as none of the studies was conducted in his country, he had no data. He sai… - Case
Ethics approval for audit 3
In this case, an international organisation wished to study the use of various regimens for medical termination of pregnancy in a developing world setting where termination of pregnancy is not supported by the state. They have performed an audit and have obtained data which will be of considerable value in other similar settings around the world. However, they are not willing to state the ident… - Case
Request for a retraction of a retraction
In October 2000, a journal published a retraction of a February 2000 publication of a research paper. In the same issue the dean of the corresponding author’s medical school reported the findings of an investigational committee that found, contrary to what was stated in the paper: · There was no ethics committee… - Case
Dual submission
Paper 1 was submitted to journal A. The paper dealt with monitoring of a chemical element in various occupations in a range of workplaces. Samples were taken from the workplace air and bodily fluids of the workers, and conclusions were drawn about what metabolite should be measured in order to estimate a worker’s dose of the element. The chosen reviewers were experts in relevant biological moni… - Case
Problem with figures
(1) An article was published after peer review. Shortly after online publication we received a message from a reader (an academic who works in the same field as the authors) notifying us of a major concern with one of the figures in the article. “I am writing with regard of manuscript XXX recently published in XXX. These studies raise significant expectations in XXX patients, because the… - Case
Accusation of theft of a model
During refereeing of an article, one of the referees made an accusation of theft regarding a model described in the article. The referee and the authors had been collaborating on a review article previously, but had fallen out. The journal requested evidence from the parties. This involved several rounds of requests to the accuser, as the journal felt that the accuser was not providing anything… - Case
Allegations of scientific fraud and unethical conduct of experiments with attempts to silence the whistleblower
…The allegations of fraud A paper reported a radioisotope test for diagnosis of a speci?c,acute,neurological disease with 100% accuracy. Replication studies failed to con?rm the ?ndings and suggested that the test is positive in a… - Case
Ownership of an idea
A paper was submitted describing a novel technique for preparing tissue, which was noted immediately by a referee to be a modification of a method used by another researcher. The other researcher is thanked but is not included in the author list. The referee asks for advice as he feels that he is in a grey area of ownership of an idea and the degree of novelty needed to make it a “new” idea. T… - Case
Ethical approval and fabrication of results
A group of authors, based in private practice, submitted three manuscripts to Journal A and one to Journal B. All the manuscripts described the application and effectiveness of a spinal manipulation technique. The first manuscript in Journal A was a case series of 21 patients. After publication, a member of the journal’s editorial board pointed out several flaws in the study design, incl… - Case
Single patient trials and lack of data
The editor received a paper describing two single patient trials. Both peer reviewers recommended publication, although each of them pointed out the absence of real data. It was an unusual case where parents with small children were involved in a series of challenges to ascertain whether the babies were allergic to cows’ milk. The authors explained the lack of data by saying that the study was… - Case
Possible malpractice revealed in a case report
We received a case report describing the diagnosis and treatment of a middle-aged woman who presented to a gastroenterology service in England with weight loss and a right iliac fossa mass. The authors did a barium swallow, duodenal and gastric biopsies, and diagnosed Crohn’s disease by the radiological appearances on follow-through. They did not do a colonoscopy, or biopsy the mass in the term… - Case
Retraction of false authorship
Dr X asked for a statement to be published to the effect that the letter he had published in the journal with two co-authors was not based on any work that he had done, but on that of his colleagues. The editor asked the other two authors why they had signed a copyright form in these circumstances. Both authors stated that they had not signed any such form, and when presented with a copy, state… - Case
Dispute between authors and a reviewer
A concise report on a rare disease was submitted and sent out to an internationally renowned reviewer in the field. He felt that some of the data had been obtained in his unit, and this had not been acknowledged by the authors. The authors responded that the tests had been performed in their own laboratory, but that the scans had indeed been done elsewhere. The editor suggested that perhaps the… - Case
CV study: was ethics approval and consent required?
A submitted paper detailing the negative experiences of overseas doctors applying for a training post in a district general hospital was poorly presented and scientifically weak, but on a topic of great interest and importance. The study consisted of an analysis of the CVs of the applicants and an analysis of responses to questionnaires sent to them with their rejection letters. Over a third of… - Case
Plagiarism and possible fraudulent publication
An article written by eminent doctors on a subject of great public interest, with implications for public health policy, was published in Journal A. They subsequently wrote to Journal A, indicating that an article had been published in Journal B, which heavily plagiarised theirs. The editor of Journal A wrote to the authors of the second paper, but has received no satisfactory replies. The seco… - Case
A highly critical obituary
A journal published a highly critical obituary, which provoked uproar and prompted the deceased’s family to complain to the national body responsible for regulating the media. The journal believed that the basis of the criticisms were accurate and acknowledged that it had not cited sufficient evidence in the obituary. The journal was considering whether to publish the evidence in full. The jour… - Case
Going public on potential fraud
A research article published some time ago detailed an invasive test. The authors obtained informed consent from the patients, but did not seek ethics committee approval. Subsequently, the journal published correspondence from X, detailing the article’s problems. X and others had attempted to replicate the study and had failed to achieve the accuracy levels as described. X stated that this was… - Case
Possible deception because of omission of important information
A large study—parts of which have been published in several major journals— purported to show that a drug may reduce side effect X without acting through an important intermediate process Y. This suggests that the drug may have important advantages over similar drugs in its class, and indeed it had been marketed as such. But a critic thinks that the drug may indeed act through the intermediate… - Case
A problematic obituary
A short obituary for a recently deceased doctor was received. Just before the issue went to print, one of the editors recognised the deceased as having been at the centre of disciplinary proceedings for having had a sexual relationship with a patient. As a result, he had been removed from the medical register for professional misconduct around two years before his death. This was not mentioned… - Case
Plagiarism and possible fraud
The authors of a paper published in another journal wrote to the editor of Journal A, complaining of apparent blatant plagiarism of their work by N et al. , whose paper had been published in the journal earlier in the year. Further investigation revealed that the text of the two papers was almost identical. S et al. had used one drug and N et al. had used a different one of the same class. The…