Data sharing is increasingly viewed as an essential step in improving research transparency and reproducibility (Taichman et al, 2016; Vickers, 2006). There has been a lot of discussion on the imperative for data sharing in the biomedical arena, particularly of publically funded research. As a result, there are many disciplines where proposals for data sharing are being discussed.
The topic for discussion at the next Forum (12 February 2016, 3.00pm GMT - more details to follow shortly) is ‘Data sharing’. Data sharing is increasingly viewed as an essential step in improving research transparency and reproducibility. There has been a lot of discussion on the imperative for data sharing in the biomedical arena, particularly of publicly funded research. As a result, there are many disciplines where proposals for data sharing are being discussed.
There is growing interest in sharing of research data, as data sharing is expected to accelerate research and increase accountability. Sharing of data underlying published research is an increasingly important consideration for peer-reviewed journals, and some journals require researchers to state their data sharing policy in published articles. However, the field of clinical trials has been slow to adopt a culture of data transparency.
Following publication of an article, a reader posted a comment raising some questions about the data analysis in the study and the availability of the dataset. We followed-up with the authors and they offered to share the dataset with the reader—the dataset involves genetic information from potentially identifiable patients and as a result the authors indicated that the deposition of the data was not possible due to patient privacy concerns. After several months the reader indicated that he had not received the dataset from the authors and that he had discussed the study with a member of the editorial board who shared the concerns about the reliability of the results reported. We further followed-up with the authors to reiterate the request for the dataset and they made the dataset available to the editors and the reader.
The reader has re-analyzed the datasets provided by the authors and he indicates that his results do not support the conclusions reported in the article. The re-analysis has been evaluated by the editorial board member who previously commented on the article and he agreed that the reliability of the findings in the article is compromised by the results of the re-analysis. We asked the authors to provide a response to the results of the re-analysis and we indicated that, in the light of the concerns raised, it may be necessary to consider retraction of the article. The authors have replied and offered to collaborate with the reader in further analyses, however they suggest that the differences in the results may be due to the different methodologies employed for the analyses and they have not formally agreed to retract the article.
We have offered the reader to submit his re-analysis for publication but he is not interested in doing this; he is however willing for us to make his re-analysis publicly available via a public notification on the published article if we decide that such a notification is necessary.
In the light of the concerns raised about the study, should we post a formal public notification on the article in order to alert readers of the concerns about the validity of the findings? If so, would it be appropriate to proceed with a retraction or given that the authors have not agreed to this, consider instead the publication of an expression of concern?
The Forum suggested that a better course of action would have been if the editor had asked the authors for their comments on the re-analysis, and then submitted the results of the re-analysis and the authors comments to an independent expect to review.
Although the reader is happy to have the re-analysis attached to a commentary, this will not be formally indexed or linked to the original article. The Forum agreed that ideally, the reader should publish the re-analysis. The suggestion was for the editor to try to persuade the reader to publish the results of the re-analysis. Getting the re-analysis published formally is the best option. If the reader still refuses to publish, then the editor should ask the authors to respond to the re-analysis and then ask an independent reviewer to look at all of the data and then publish this as a comment on the article itself.
In the light of the advice provided by the COPE Forum, the editor followed-up with the reader and he has agreed to submit his re-analysis for publication. The editor is awaiting the submission of the piece describing the re-analysis.